Various Myo1 isoforms have specialized functions. Collectively, Myo1 isoforms help in mechanical regulation of membrane architecture by coupling it with actin cytoskeleton. Myo1 proteins are further classified as short tailed (eg 1B/1C/1D) or long tailed (eg 1E/1F) based on the absence or presence of glycine/proline/alanine rich (TH2) and SH3 domains (TH3) in the tail region. Myo1 isoforms associate with cell membrane by the Tail Homology 1 (TH1) domain that contains a lipid-binding, PH like domain. IntroductionMyo1 proteins are ATP-driven actin-bound motor proteins that are commonly monomeric (single headed) in nature, unlike dimeric Myosin II (Myo2) molecules. Therefore, our results demonstrate a potential role for Myo1 in the maintenance and formation of furrow, blastodisc morphology, cell-division and LD organization within the blastodisc during early embryogenesis.
0 kommentar(er)
